Pathology Outlines

Stains & CD markers
CD120-129

Last author update: 1 August 2013

Last staff update: 24 April 2024

Copyright: 2003-2024, PathologyOutlines.com, Inc.

PubMed Search: tnfr1[title], CD121a OR CDw121b, CD122, CD123[title], CD124, IL5RA[title], IL5RA[title], CD126[title], CD127[title], CD129

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Table of Contents

CD120 | CD121a | CDw121b | CD122 | CD123 | CD124 | CDw125 | CD126 | CD127 | CD128 | CD129

Cite this page: Pernick N. CD120-129. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd120.html. Accessed December 18th, 2024.

CD120

CD120a: aka TNFR1, receptor for tumor necrosis factor alpha and beta, type I; receptor binding to ligand causes apoptosis
CD120b: aka receptor for tumor necrosis factor (TNF) alpha and beta, type II

CD121a

Also known as Interleukin 1 receptor (IL-1R) type I, IL1-alpha
Interleukin-1, an inflammatory mediator, consists of 2 separate but related proteins, IL1-alpha and IL1-beta
Positive staining - normal: T cells, thymocytes, fibroblasts, endothelial cells

CDw121b

Also known as Interleukin 1 receptor (IL-1 R) type II, IL1-beta
May inhibit IL1 activity by acting as a decoy target for IL1
Positive staining - normal: B cells, macrophages

CD122

Aka Interleukin 2 receptor beta chain (IL-2R beta)
Critical component of IL-2 and IL-15-mediated signaling
Positive staining - normal: NK cells, B cells, T cells, monocytes

CD123

See CD123
Aka Interleukin 3 receptor alpha subunit
Associates with the GM-CSF receptor (GMR beta)
Uses by pathologists: important for diagnosis of blastic plasmacytic dendritic cell neoplasm (BPDCN)
Positive staining - normal: plasmacytoid monocytes (bright with flow cytometry) (Am J Surg Pathol 2002;26:852)

CD124

Aka Interleukin 4 receptor
Receptor subunit for Interleukin-4 and 13
Positive staining - normal: mature B cells, T cells; hematopoietic precursors; fibroblasts, endothelial cells

CDw125

Aka Interleukin 5 receptor alpha subunit (IL5RA)
Therapeutic target of eosinophilic inflammation involved in bronchial asthma
Positive staining - normal: eosinophils, activated B cells, basophils

CD126

Aka Interleukin 6 receptor
Continuous expression of IL-6 and CD130, ligands for CD126, causes hypergammaglobulinemia, glomeruloproliferative nephritis and lymphoid infiltration in some organs
Dysregulated stimulation may cause myeloma and plasmacytoma
Positive staining - normal: T cells, monocytes, activated B cells, hepatocytes

CD127

Aka Interleukin 7 receptor
Positive staining - normal: B cell precursors, most T cells, monocytes

CD128

See CD181 / CD128

CD129

Reserved for Interleukin 9 receptor

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