Stains & CD markers
CD110-119
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD110 [title], CD111[title], CD112[title], nectin-3[title], CD114[title], CD115[title], CD116[title], CD118[title], CDw119[title]
CD110-119
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 24 June 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD110 [title], CD111[title], CD112[title], nectin-3[title], CD114[title], CD115[title], CD116[title], CD118[title], CDw119[title]
Cite this page: Pernick N. CD110-119. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd110.html. Accessed November 27th, 2024.
CD110
- Also called thrombopoietin receptor (TPO-R), myeloproliferative leukemia virus oncogene (MPL)
- Binding to thrombopoietin induces megakaryocyte proliferation and differentiation and prevents apoptosis
- Mutations present in some patients with congenital amegakaryocytic thrombocytopenia, characterized by severe congenital thrombocytopenia with no megakaryocytes in the bone marrow (Hum Mutat 2006;27:296)
- MPL mutations in myelofibrosis patients are associated with more severe anemia (Br J Haematol 2007;137:244)
- Thrombopoietin receptor agonists may be useful for treating thrombocytopenia (Blood 2007;109:4739)
- Uses by pathologists: differentiate essential thrombocythemia (variable but weak / negative staining) from reactive thrombocytosis (positive staining) (Blood 2002;99:4131)
- Positive staining - normal: hematopoietic stem cells and progenitor cells, megakaryocytes and progenitors, platelets (J Transl Med 2006;4:9)
- References: OMIM: 159530 [Accessed 29 April 2021], Gene: MPL proto-oncogene, thrombopoietin receptor [Accessed 29 April 2021]
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CD110: protein and site, various mutations
CD111
- Also known as poliovirus receptor related 1 (PRR1), nectin1
- Widely expressed adhesion molecule that is a component of the adherens junction; receptor for herpes simplex viruses 1 and 2
- Positive staining - normal: cells from myeloid, monocyte, megakaryocytes and erythroid lineage, epithelial cells, neurons, endothelium
CD112
CD114
- Also known as granulocyte colony stimulating factor receptor, G-CSFR
- Specific regulator of myeloid proliferation and differentiation
- Mutations present in some patients with severe congenital neutropenia
- Positive staining - normal: granulocytes (all), monocytes, platelets, endothelium, placenta, trophoblastic cells
- Positive staining - malignant: cultured tumor cells
- Negative staining: eosinophils, lymphocytes, erythrocytes
CD115
- Also known as c-fms, receptor for macrophage colony stimulating factor, CSF-1R
- Localized on cytoplasmic membrane; mediates biologic activity of CSF-1
- v-fms is a viral oncogene present in the feline McDonough sarcoma virus (has several substitute mutations)
- Related to platelet derived growth factor receptor, c-kit, vascular endothelial growth factor receptor, fibroblast growth factor receptor, high affinity nerve growth factor (TrkA)
- Deficiency causes reduced osteoclasts and macrophages, abnormal bone remodeling and osteopetrosis, abnormal breast development and decreased fertility
- Positive staining - normal: macrophages and precursors, osteoclasts, placental trophoblast, breast tissue, microglia, neurons, astrocytes
- Positive staining - malignant: 10% AML, some endometrial, ovarian and breast cancers, vascular smooth muscle cells in atheromas, choriocarcinoma cells
CD116
CD117
- See CD117
