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Breast

Other invasive carcinoma subtypes, WHO classified

Mixed NST

Last author update: 1 August 2012

Last staff update: 18 December 2024 (update in progress)

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PubMed search: ductal [title] AND lobular [title] carcinoma breast

Table of Contents

Cite this page: Roychowdhury M. Mixed NST. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastmixedNST.html. Accessed December 26th, 2024.

Definition / general

Mixture of ductal carcinoma NOS and lobular carcinoma

Terminology

Not part of WHO breast classification

Clinical features

Age of onset similar to infiltrating ductal carcinoma
Survival similar to pure ductal or lobular types
Compared to pure ductal carcinomas, have higher rate of second primary breast cancers (World J Surg Oncol 2010;8:51, Breast Cancer Res Treat 2009;114:243)
Compared to pure lobular carcinomas, have lower rate of synchronous contralateral breast cancer
4% of breast carcinomas
89% have DCIS, 31% have LCIS
41% have positive lymph nodes at diagnosis
May have higher plasma levels of Soluble human leukocyte antigen s(HLA)-G (Anticancer Res 2012;32:1021)

Microscopic (histologic) description

Definite features of invasive ductal carcinoma and invasive lobular carcinoma in same tumor

Microscopic (histologic) images

Images hosted on other servers:

Mixed ductal / lobular tumor

E-cadherin immunostaining of ductal components of tumor

Positive stains

E-cadherin patterns include no staining (similar to lobular), full staining (similar to ductal) or staining of ductal areas only (Am J Clin Pathol 2001;115:85)

Differential diagnosis

Tubulolobular carcinoma: typical areas of invasive lobular carcinoma with cords of single file cells, which merge with small round to angulated tubules with minute or undetectable lumina
Collision of two separate neoplasms

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