Bladder & urothelial tract
Other tumors
Metastases
Author: Monika Roychowdhury, M.D.
Last author update: 1 December 2014
Last staff update: 30 October 2020
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Bladder metastases [title]
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology images | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Roychowdhury M. Metastases. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bladdermets.html. Accessed December 26th, 2024.
Definition / general
- Most common primaries are breast and melanoma; also lung, pancreas, ovary and stomach
- Associated with widely disseminated disease
- Urothelium is usually spared
- Tumors may also arise from local extension from prostate, uterine cervix or rectum
- Difficult to distinguish bladder adenocarcinoma morphologically from extension of colonic adenocarcinoma
- Renal cell metastases: rare (< 40 reported cases); usually men age 35 - 69 years who present with gross hematuria or urinary obstruction if tumor is in bladder neck; metastases also present in other organs; poor prognosis (Mod Pathol 1999;12:351); may be due to hematogenous spread, retrograde spread from renal vein or renal hilar lymphatics or direct intraluminal transit
Case reports
- 45 year old woman with metastasis from appendiceal mucinous adenocarcinoma (BMC Cancer 2010;10:62)
- 67 year old woman with colonic metastasis (Surg Today 2010;40:1093)
- 68 year old woman with metastasis from breast cancer (J Clin Oncol 2007;25:4308)
- 90 year old woman with metastasis of gastric cancer (World J Surg Oncol 2005;3:55)
- Bladder metastases of melanoma (Med Oncol 2011;28:667, Arch Esp Urol 2002;55:1277)
- Bladder metastasis from pancreatic adenocarcinoma (Urol Radiol 1992;13:187)
- Bladder metastasis from renal cell carcinoma (J Urol 2010;184:726, Urologe A 2010;49:407 ,Can J Urol 2009;16:4611, Int J Urol 2003;10:453)
Microscopic (histologic) description
- Morphology varies based on the primary tumor
- Metastatic renal cell carcinoma: delicate fibrovascular stroma with abundant sinusoidal vessels; nests of polygonal cells with abundant clear cytoplasm and nuclei ranging from small and hyperchromatic with inconspicuous nucleoli to large irregular nuclei with prominent nucleoli; may resemble urothelial carcinoma with clear cell features
Microscopic (histologic) images
Images hosted on other servers:
Metastatic appendiceal
mucinous adenocarcinoma
- various images
Metastatic breast cancer: H&E, PR, HER2
Cytology images
Contributed by Bonnie Choy, M.D.
Prostatic adenocarcinoma
NKX3.1
Colorectal adenocarcinoma
Renal cell carcinoma
Positive stains
Differential diagnosis
- Colorectal carcinoma (extension): positive for CK20, villin, beta catenin (nuclear)
- Prostatic adenocarinoma (extension): positive for PSA, PSAP, AMACR, Leu7
- Urothelial carcinoma with glandular differentiation: positive for CK7, CK20, 34betaE12, Uroplakin, Thrombomodulin
Additional references
