Table of contents
Bone marrow - neoplastic myeloid
General:books
AML general (pending)
flow cytometry
how to do a bone marrow biopsy (procedure) (pending)
AML with recurrent genetic abnormalities:AML with BCR::ABL1
AML with CEBPA mutation (WHO-HAEM5-biallelic or ICC bzip)
AML with mutated NPM1
AML with inv(3)(q21.3;q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBFB::MYH11
AML with t(6;9)(p23;q34); DEK::NUP214
AML with t(8;21)(q22;q22); RUNX1::RUNX1T1
AML with t(9;11)(p22;q23); KMT2A::MLLT3
AML with other KMT2A rearrangements
AML with other MECOM rearrangements (pending)
APL with PML::RARA
AML with other rare recurrent translocations:AML with FUS::ERG (pending)
AML with KAT6A::CREBBP
AML with RUNX1T3(CBFA2T3)::GLIS2
AML with t(1;3)(p36;q21); RDM16::RPN1
AML (megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15::MRTF1
AML with t(3;5)(q25.3;q35.1); NPM1::MLF1 (pending)
AML with t(5;11)(q35.2;p15.4); NUP98::NSD1 (pending)
AML with t(7;12)(q36.3;p13.2) / ETV6::MNX1 (pending)
AML not otherwise specified:AML with minimal differentiation (FAB AML M0)
AML without maturation (FAB AML M1)
AML with maturation (FAB AML M2)
Acute myelomonocytic leukemia (AMML)
AML M5
M5a
M5b
AML M6
AMKL M7
acute basophilic leukemia
AML with pseudo-Chediak-Higashi anomaly
AML hypocellular
Other AML entities defined by the WHO:acute panmyelosis with myelofibrosis
AML with myelodysplasia defining abnormalities
myeloid leukemia associated with Down syndrome
myeloid sarcoma
therapy related myeloid neoplasm (therapy related AML)
transient abnormal myelopoiesis associated with Down syndrome
Myelodysplastic syndromes / neoplasms (MDS):WHO classification - MDS
MDS-general
with del(5q)
MDS prognostic scoring
MDS, hypoplastic (pending)
MDS in childhood
MDS with single lineage dysplasia
MDS with mutated SF3B1
MDS with multilineage dysplasia
MDS with biallelic TP53 inactivation
MDS with mutated TP53 (pending)
MDS with excess blasts
MDS unclassifiable
refractory cytopenia of childhood (pending)
Premalignant clonal cytopenias:clonal cytopenia of undetermined significance (CCUS) (pending)
clonal hematopoiesis of indeterminate potential (CHIP) (pending)
paroxysmal nocturnal hemoglobinuria (PNH)
VEXAS (pending)
Myeloproliferative neoplasms (MPN):chronic eosinophilic leukemia
chronic myeloid leukemia (CML), BCR::ABL1 positive
chronic neutrophilic leukemia
essential thrombocythemia
MPN unclassifiable
polycythemia vera
primary myelofibrosis
MDS / MPN: atypical chronic myeloid leukemia; BCR::ABL1 negative
chronic myelomonocytic leukemia
juvenile myelomonocytic leukemia
MDS / MPN - unclassifiable
MDS / MPN with SF3B1 and thrombocytosis
Myeloid / lymphoid neoplasms with eosinophilia and gene rearrangement: PDGFRA rearrangement
PDGFRB rearrangement
ETV6::ABL1 fusion with other tyrosine kinase gene fusions (pending)
FGFR1 rearrangement
FLT3 rearrangement
JAK2
Myeloid neoplasms with germline predisposition without a constitutional disorder affecting multiple organ systems:AML with germline CEBPA mutation (pending)
myeloid or lymphoid neoplasms with germline TP53 mutation (pending)
with DDX41 mutation
Hematologic neoplasms with germline predisposition and platelet disorders:myeloid or lymphoid neoplasms with germline RUNX1 mutation
myeloid neoplasms with ANKRD26 mutation (pending)
myeloid or lymphoid neoplasms with germline ETV6 mutation (pending)
Myeloid neoplasms with germline predisposition and other organ dysfunction: Diamond-Blackfan anemia
Fanconi anemia
juvenile myelomonocytic leukemia associated with neurofibromatosis (pending)
juvenile myelomonocytic leukemia associated with Noonan syndrome-like disorder (CBL syndrome) (pending)
myeloid neoplasms with germline GATA2 mutation
myeloid neoplasms with germline SAMD9 mutation
myeloid neoplasms with germline SAMD9L mutation (pending)
severe congenital neutropenia (pending)
Shwachman-Diamond syndrome
telomere biology disorders including dyskeratosis congenita (pending)
with Down syndrome (pending)
Bone marrow - plasma cell and lymphoid neoplasms
Plasma cell neoplasms:heavy chain disease
MGUS-IgM
MGUS - non-IgM
non secretory myeloma (pending)
plasma cell leukemia
plasma cell myeloma (multiple myeloma)
plasmacytoma
POEMS syndrome (osteosclerotic myeloma)
TEMPI syndrome (pending)
Other:acute lymphoblastic leukemia / lymphoma
cryoglobulinemia
monoclonal immunoglobulin deposition diseases (pending)
primary amyloidosis
B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities:t(1;19)(q23;p13.3); TCF3::PBX1
t(5;14)(q31;q32); IGH::IL3
t(9;22)(q34;q11); BCR::ABL1
t(12;21)(p13;q22); ETV6::RUNX1
t(v;11q23); KMT2A rearranged
BCR::ABL1-like
TCF3::HLF (pending)
therapy related B ALL
with hyperdiploidy
with hypodiploidy
with iAMP21
NK and T cell precursor lymphoid neoplasms:early T cell precursor lymphoblastic leukemia
NK lymphoblastic leukemia / lymphoma
T lymphoblastic lymphoma / leukemia
Acute leukemia of ambiguous lineage: acute undifferentiated leukemia
ambiguous lineage NOS
mixed phenotype
Disorders from other chapters:
crystal storing histiocytosis
heavy chain deposition disease
light chain deposition disease
Bone marrow neoplastic stains & molecular markers:
Lymphoblastic initial panel: CD1a CD3 CD4 CD5 CD7 CD8 CD10 CD20 CD34 PAX5 TdT
Refining panel: CD19 CD56 CD79a CD99 CD117 CD123 myeloid markers
Primary marrow disorder initial screening: CD34 CD61 CD71 CD117 myeloperoxidase
Refining panel: CD11c CD14 CD42b CD64 E-cadherin glycophorin iron mast cell tryptase (pending) reticulin
Myeloma initial screening: CD138 kappa lambda
Refining panel: CD3 CD19 CD20 CD56 CD117 cyclin D1 EBER Ki67
Myeloid molecular markers: BCR::ABL1 CALR (pending) CEBPA (pending) CSF3R FLT3 IDH1 and IDH2 JAK2 MPL NPM1 PDGFRA PML::RARA RUNX1 SF3B1 (pending)
FISH: FISH overview myeloma prognostic probe sets (pending) TCL1
Next generation sequencing: NGS-general NGS library prep (pending)
Bone marrow neoplastic stains & molecular markers:
Lymphoblastic initial panel: CD1a CD3 CD4 CD5 CD7 CD8 CD10 CD20 CD34 PAX5 TdT
Refining panel: CD19 CD56 CD79a CD99 CD117 CD123 myeloid markers
Primary marrow disorder initial screening: CD34 CD61 CD71 CD117 myeloperoxidase
Refining panel: CD11c CD14 CD42b CD64 E-cadherin glycophorin iron mast cell tryptase (pending) reticulin
Myeloma initial screening: CD138 kappa lambda
Refining panel: CD3 CD19 CD20 CD56 CD117 cyclin D1 EBER Ki67
Myeloid molecular markers: BCR::ABL1 CALR (pending) CEBPA (pending) CSF3R FLT3 IDH1 and IDH2 JAK2 MPL NPM1 PDGFRA PML::RARA RUNX1 SF3B1 (pending)
FISH: FISH overview myeloma prognostic probe sets (pending) TCL1
Next generation sequencing: NGS-general NGS library prep (pending)
Index (Alphabetical table of contents)
A-E:acute basophilic leukemia
acute lymphoblastic leukemia / lymphoma
Acute myelomonocytic leukemia (AMML)
acute panmyelosis with myelofibrosis
acute undifferentiated leukemia
ambiguous lineage NOS
AMKL M7
AML (megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15::MRTF1
AML general (pending)
AML hypocellular
AML M5
AML M6
AML with CEBPA mutation (WHO-HAEM5-biallelic or ICC bzip)
AML with BCR::ABL1
AML with FUS::ERG (pending)
AML with germline CEBPA mutation (pending)
AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBFB::MYH11
AML with inv(3)(q21.3;q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
AML with KAT6A::CREBBP
AML with maturation (FAB AML M2)
AML with minimal differentiation (FAB AML M0)
AML with mutated NPM1
AML with myelodysplasia defining abnormalities
AML with other KMT2A rearrangements
AML with other MECOM rearrangements (pending)
AML with pseudo-Chediak-Higashi anomaly
AML with RUNX1T3(CBFA2T3)::GLIS2
AML with t(1;3)(p36;q21); RDM16::RPN1
AML with t(3;5)(q25.3;q35.1); NPM1::MLF1 (pending)
AML with t(5;11)(q35.2;p15.4); NUP98::NSD1 (pending)
AML with t(6;9)(p23;q34); DEK::NUP214
AML with t(7;12)(q36.3;p13.2) / ETV6::MNX1 (pending)
AML with t(8;21)(q22;q22); RUNX1::RUNX1T1
AML with t(9;11)(p22;q23); KMT2A::MLLT3
AML without maturation (FAB AML M1)
APL with PML::RARA
atypical chronic myeloid leukemia; BCR::ABL1 negative
BCR::ABL1-like
blastic plasmacytoid dendritic cell neoplasm
chronic eosinophilic leukemia
chronic myeloid leukemia (CML), BCR::ABL1 positive
chronic myelomonocytic leukemia
chronic neutrophilic leukemia
clonal cytopenia of undetermined significance (CCUS) (pending)
clonal hematopoiesis of indeterminate potential (CHIP) (pending)
cryoglobulinemia
cutaneous mastocytosis
Diamond-Blackfan anemia
early T cell precursor lymphoblastic leukemia
essential thrombocythemia
ETV6::ABL1 fusion with other tyrosine kinase gene fusions (pending)
F-N:Fanconi anemia
FGFR1 rearrangement
flow cytometry
FLT3 rearrangement
heavy chain disease
how to do a bone marrow biopsy (procedure) (pending)
idiopathic hypereosinophilic syndrome
JAK2
juvenile myelomonocytic leukemia
juvenile myelomonocytic leukemia associated with neurofibromatosis (pending)
juvenile myelomonocytic leukemia associated with Noonan syndrome-like disorder (CBL syndrome) (pending)
M5a
M5b
mast cell sarcoma (pending)
MDS / MPN - unclassifiable
MDS / MPN with SF3B1 and thrombocytosis
MDS in childhood
MDS prognostic scoring
MDS unclassifiable
MDS with biallelic TP53 inactivation
MDS with excess blasts
MDS with multilineage dysplasia
MDS with mutated SF3B1
MDS with mutated TP53 (pending)
MDS with single lineage dysplasia
MDS, hypoplastic (pending)
MDS-general
MGUS - non-IgM
MGUS-IgM
mixed phenotype
monoclonal immunoglobulin deposition diseases (pending)
MPN unclassifiable
myeloid leukemia associated with Down syndrome
myeloid neoplasms with ANKRD26 mutation (pending)
myeloid neoplasms with germline GATA2 mutation
myeloid neoplasms with germline SAMD9 mutation
myeloid neoplasms with germline SAMD9L mutation (pending)
myeloid or lymphoid neoplasms with germline ETV6 mutation (pending)
myeloid or lymphoid neoplasms with germline RUNX1 mutation
myeloid or lymphoid neoplasms with germline TP53 mutation (pending)
myeloid sarcoma
NK lymphoblastic leukemia / lymphoma
non secretory myeloma (pending)
O-Z:paroxysmal nocturnal hemoglobinuria (PNH)
PDGFRA rearrangement
PDGFRB rearrangement
plasma cell leukemia
plasma cell myeloma (multiple myeloma)
plasmacytoma
POEMS syndrome (osteosclerotic myeloma)
polycythemia vera
primary amyloidosis
primary myelofibrosis
refractory cytopenia of childhood (pending)
severe congenital neutropenia (pending)
Shwachman-Diamond syndrome
systemic mastocytosis
T lymphoblastic lymphoma / leukemia
t(12;21)(p13;q22); ETV6::RUNX1
t(1;19)(q23;p13.3); TCF3::PBX1
t(5;14)(q31;q32); IGH::IL3
t(9;22)(q34;q11); BCR::ABL1
t(v;11q23); KMT2A rearranged
TCF3::HLF (pending)
telomere biology disorders including dyskeratosis congenita (pending)
TEMPI syndrome (pending)
therapy related B ALL
therapy related myeloid neoplasm (therapy related AML)
transient abnormal myelopoiesis associated with Down syndrome
VEXAS (pending)
WHO classification - MDS
with DDX41 mutation
with del(5q)
with Down syndrome (pending)
with hyperdiploidy
with hypodiploidy
with iAMP21
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