Vulva
Nonneoplastic disorders
Multinucleated atypia

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 4 October 2017, last major update October 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Vulvar multinucleated atypia

Cite this page: Roychowdhury, M. Multinucleated atypia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/vulvamultinucleatedatypia.html. Accessed November 19th, 2017.
Definition / general
  • Histologic pattern of multinucleated keratinocytes in basal and middle layers of squamous epithelium of vulva (Am J Surg Pathol 1994;18:1233)
  • May mimic human papillomavirus (HPV) related squamous dysplasia but not associated with HPV
Case reports
Gross description
  • May present as flesh colored vulvar papules
Microscopic (histologic) description
  • Multinucleated keratinocytes without significant nuclear atypia in lower to middle epithelial layers of otherwise normal appearing squamous epithelium
  • These multinucleated cells may contain 2 - 10 nuclei, often prominent nucleoli
  • No surface atypia, no hyperchromasia, no pleomorphism
  • No significant inflammation
Negative stains