Vagina
Malignant tumors
Small cell carcinoma

Author: Shweta Gera, M.D. (see Authors page)
Editor: Arzu Buyuk, M.D.

Revised: 29 September 2017, last major update September 2014

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Small cell carcinoma vagina [title]

Cite this page: Gera, S. Small cell carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/vaginasmallcell.html. Accessed October 23rd, 2017.
Definition / general
  • Poorly differentiated neuroendocrine tumor with characteristic morphological features, arising in vagina with no evidence of metastasis from any other site
  • Tumor has histological, immunohistochemical and ultrastructural features similar to small cell carcinoma arising in any other organ including female genital tract (Patholog Res Int 2011;2011:306921)
Terminology
  • Previously called oat cell carcinoma
Epidemiology
Sites
  • Can occur anywhere in vagina - no specific predilection
Clinical features
Diagnosis
  • Clinical findings and pathological features with no evidence of similar tumor elsewhere in the body
Laboratory
Radiology description
Radiology images

Images hosted on other servers:
Missing Image

MRI, PET / CT

Missing Image

Solid mass

Prognostic factors
  • Poor prognosis and aggressive behavior
  • Most patients present with metastasis and die within 2 years (Rare Tumors 2013;5:e58)
Case reports
Treatment
  • No standard therapy
  • Various management options are surgical resection, chemotherapy, radiotherapy or combinations of these therapies
  • Combination cisplatin + etoposide can be used (Rare Tumors 2013;5:e58)
  • Small lesions localized to upper vagina can be treated by radical hysterectomy, partial vaginectomy and pelvic lymphadenectomy (Case Rep Obstet Gynecol 2013;2013:827037)
Clinical images

Images hosted on other servers:
Missing Image

Vaginal tumor

Gross description
Gross images

Images hosted on other servers:
Missing Image

No hemorrhage or necrosis

Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Pleomorphic
hyperchromatic
nuclei with finely
granular chromatin

Missing Image

Diffuse infiltration of small darkly stained cells

Missing Image

Scant cytoplasm, inconspicuous nucleoli

Missing Image

H&E, AE1 / AE3, chromogranin A, p63


Missing Image

Synaptophysin+

Missing Image

Chromogranin

Missing Image

NSE

Missing Image

Chromogranin, synaptophysin

Cytology description
  • Tumor cells are dispersed as single cells or arranged as loosely cohesive sheets or gland-like aggregates
  • Cells range from small to large with pleomorphic, angulated hyperchromatic nuclei that may show nuclear molding and smear artifact
  • Atypical cells have high N/C ratio or bare hyperchromatic nuclei (Rare Tumors 2013;5:e58)
  • Mitotic figures are common and karyorrhectic debris can be identified in the background (Cytojournal 2013;10:17, Diagn Cytopathol 2001;24:46)
Cytology images

Images hosted on other servers:
Missing Image

ThinPrep, Pap

Positive stains
Electron microscopy description