Vagina
Malignant tumors
Myeloid (granulocytic) sarcoma

Author: Shweta Gera, M.D. (see Authors page)
Editor: Arzu Buyuk, M.D.

Revised: 27 September 2017, last major update May 2014

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Granulocytic sarcoma vagina

Cite this page: Gera, S. Myeloid (granulocytic) sarcoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/vaginagranulocyticsarcoma.html. Accessed December 15th, 2017.
Definition / general
  • Tumor mass of myeloblasts or immature myeloid cells occurring in vagina, which may be the initial site of presentation of the disease (Ann Diagn Pathol 2012;16:374)
Terminology
Epidemiology
Sites
  • Can occur anywhere in vagina
Etiology
  • Extramedullary manifestation of AML, may occur without a prior or subsequent diagnosis of an AML, myeloproliferative neoplasm or myelodysplastic syndrome
  • It can be the initial manifestation of relapse in a previously treated AML in remission (Ann Diagn Pathol 2012;16:374)
Clinical features
Diagnosis
  • Based on spectrum of findings including clinical history, cytology / biopsy, immunohistochemical features, flow cytometry and molecular / FISH analysis
  • Diagnostic challenge due to rarity at this site, its undifferentiated morphology, lack of obvious myeloid feature (Ann Diagn Pathol 2012;16:374)
Radiology description
  • CT and MRI help differentiate from abscess or hematoma
  • FDG PET CT helps document location, tumor size, presence of multiple lesions (Am J Blood Res 2013;3:265)
Prognostic factors
Case reports
Treatment
Gross description
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:

In muscle

Myeloperoxidase, uterine cervix

Cytology description
  • Single cells with small to intermediate size, high N:C ratio and scant cytoplasm
Positive stains
Negative stains
Flow cytometry description
  • Depending on the differentiation, can be positive for CD34, CD117, CD11b, CD64, MPO and CD33 (J Low Genit Tract Dis 2010;14:136); also may be positive for CD45, CD13, CD36, CD16, CD15, HLA-DR and CD56
Molecular / cytogenetics description
  • t(8;21)(q22; q22), inv(16)(p13q22) or t(16;16)(p13q22) may be observed
  • Monoblastic differentiation may be associated with translocations involving 11q23 (Ann Diagn Pathol 2012;16:374)
  • Abnormalities detected by FISH include monosomy 7 (10.8%); trisomy 8 (10.4%), rearrangements of 11q23 (8.5%) and rarely t(8;21) (Ann Diagn Pathol 2012;16:374)
Differential diagnosis
Additional references