Uterus
Stromal tumors
Plexiform tumor / tumorlet

Author: Mohamed Desouki, M.D. (see Authors page)

Revised: 2 February 2017, last major update September 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: plexiform tumor uterus

Cite this page: Plexiform tumor / tumorlet. PathologyOutlines.com website. http://pathologyoutlines.com/topic/uterusplexiformtumor.html. Accessed April 28th, 2017.
Definition / general
  • Benign neoplasms related to endometrial stroma closely related to uterine tumors resembling ovarian sex cord tumors
  • Note: tumor not included in the World Health Organization tumor classification
Terminology
  • Endometrial glomus tumour, solid angioma
Epidemiology
  • Very rare tumors with an average age of 48 - 60 years
Etiology
  • Unknown
Clinical features
  • Incidental finding
Prognostic factors
  • Mostly behaves in benign fashion
Gross description
  • Minute neoplasms usually 1 cm or less, but may be large or multiple
  • Nodular and well circumscribed or may exhibit irregular borders
Microscopic (histologic) description
  • Cells with crumbled nuclei, indistinct cytoplasm arranged in cords or rows in branching pattern separated by hyalinized stroma
  • The cells may merge with foam cells similar to luteinized ovarian stromal cells
  • Mitotic activity is sparse
  • Tumors usually identified at endomyometrial junction
  • Also reported in adenomyosis and in endometrial polyp
Positive stains
Electron microscopy description
  • Appears to have smooth muscle origin by EM