Uterus
Non tumor
Endometritis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 January 2017, last major update November 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: endometritis [title] NOT tumor

Related topics: Acute endometritis, Chronic endometritis

Cite this page: Endometritis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/uterusendometritis.html. Accessed October 21st, 2017.
Definition / general
  • Endocervix normally forms barrier to ascending infection
  • Chlamydia: associated with severe acute / chronic inflammation
  • Coccidiomycosis: may be secondary to resolved primary lung infection
  • Giant cell arteritis: may involve uterus as isolated finding or part of generalized giant cell arteritis
  • Granulomas: due to sarcoid, tuberculosis, CMV (Am J Surg Pathol 1992;16:716) or post laser ablation for postmenopausal bleeding
  • Hematometra: blood within uterine cavity, usually due to cervical occlusion; endometrial mucosa is replaced by lipid laden histiocytes (xanthogranulomatous endometritis); called "ceroid containing histiocytic granuloma" if histiocytes contain yellowish brown cytoplasmic pigment
  • Intrauterine device (IUD): 65% have abnormal endometrium at biopsy; often focal or extensive chronic endometritis, necrosis and squamous metaplasia; may be associated with PID and tubo-ovarian abscesses; IUD infection rate is 13% - actinomyces common
  • Pneumopolycystic: one case reported to date, appears to resolve spontaneously (Am J Surg Pathol 2006;30:258)
  • Pyometra: pus in endometrial cavity; due to obstruction (benign cervical stricture) and infection; occasionally due to carcinoma
  • Sarcoidosis: granulomas usually spread to myometrium (in contrast to TB)
  • Tuberculosis: rare in US; common in other countries, where it causes infertility; plasma cells and white blood cells may be present due to secondary infection; acid fast bacilli present in tubercles or culture; granulomas tend to accumulate in superficial functional layers of endometrium, so biopsy during late secretory phase
  • Xanthogranulomatous endometritis: rare lesion of elderly with pyometra and cervical stenosis; replacement of endometrium by xanthogranulomatous inflammation composed of abundant foamy histiocytes, siderophages, giant cells, neutrophils, plasma cells and lymphocytes; also fibrosis, calcification (Infect Dis Obstet Gynecol 2007;2007:34763)
Microscopic (histologic) images

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Endometrial tuberculosis