Home   Chapter Home   Jobs   Conferences   Fellowships   Books




Reviewers: Turki Al-Hussain, M.D. (see Reviewers page)
Revised: 3 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Adults, mean age 73 years
● Urethra is the most common site of origin of malignant melanoma in the urinary tract
● Usually involves distal urethra in men and women
● Less common in bladder
● 5 year survival ~ 20% (may die of unrelated causes, Am J Surg Pathol 2000;24:785)


● Total urethrectomy plus bilateral inguinal node dissection

Gross description

● Polypoid, mean 2.6 cm

Micro description

● Vertical growth phase often has prominent nodular component
● Also radial growth phase
● Abundant eosinophilic cytoplasm with large nuclei and prominent nucleoli
● Numerous mitoses
● Melanin pigment usually present, but often focal

Differential diagnosis

● Urothelial carcinoma
● Sarcomatoid carcinoma

End of Urethra > Melanoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).