Transfusion medicine
Transfusion transmitted disease
West Nile virus and transfusions

Author: Huy Phu Pham, M.D. (see Authors page)

Revised: 2 November 2017, last major update November 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: West Nile virus transfusions "loattrfree full text"[sb]

Table of Contents
Definition / general
Cite this page: Pham, H.P. West Nile virus and transfusions. PathologyOutlines.com website. http://pathologyoutlines.com/topic/transfusionmedwestnile.html. Accessed November 23rd, 2017.
Definition / general
  • West Nile virus is a flavivirus primarily transmitted through mosquitoes, with birds as immediate hosts (Wikipedia: West Nile fever [Accessed 31 October 2017])
  • Entered North America in 1999; still epidemic in North America due to mosquito and bird vectors
  • First appeared in New York in 1999 and rapidly expanded its geographical area within 3 years
  • Symptoms: headache, new rash, generalized weakness (Transfusion 2006;46:272)
  • May cause meningoencephalitis (Am J Clin Pathol 2003;119:749)
  • Transfusion transmission resulted in 23 infections in 2002 during an outbreak
  • Detected by nucleic acid based testing although virus adheres to human red blood cells in whole blood (Clin Infect Dis 2007;45:181)
  • NAT testing was implemented in 2003
  • Use of only minipool NAT testing resulted in 7 transfusion transmission cases in 2003 - 2004

Cost effectiveness models: