Transfusion medicine
Transfusion transmitted disease
SEN virus

Author: Huy Phu Pham, M.D. (see Authors page)

Revised: 31 October 2017, last major update October 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: SEN-V virus transfusion [title]

Table of Contents
Definition / general
Cite this page: Pham, H.P. SEN virus. PathologyOutlines.com website. http://pathologyoutlines.com/topic/transfusionmedsenvirus.html. Accessed November 18th, 2017.
Definition / general
  • SEN virus (SENV) is a blood borne, single stranded, nonenveloped DNA virus
  • Discovered in 1999 in Italy, distantly related to transfusion transmitted virus (Infect Dis 2001;183:359)

Prevalence varies by region:
  • 1.8% in the U.S.
  • 10 - 22% in Japan
  • 15% in Taiwan
  • 5% in Thailand
  • 8 - 17% in Germany
  • 24% in Greece
  • At least 13% in Italy
  • Present in 40% of hemodialysis patients in Poland (Wiad Lek 2006;59:751)
  • Frequently occurs early in life; in eastern Taiwan, present in 25 - 31% of adolescents, may be associated with urbanization, probably not parenteral transmission in this group (J Gastroenterol Hepatol 2007;22:171)
  • Prevalence increases with transfusions (Pediatr Infect Dis J 2006;25:390)
  • Detected in as many as 30% of postoperative transfusion recipients (vs. 3% postoperative patients who did not receive transfusions)

  • SENV consists of 8 strains, A - H
  • Strains D and H appear to be associated with non A - E hepatitis
  • Also found in 30% of cases of transfusion-associated non A - E hepatitis in US (vs. 1.8% of healthy blood donors) but overall, considered to have weak association, at most, with hepatitis (Minerva Gastroenterol Dietol 2002;48:73, Transfusion 2005;45:1084)
  • High levels are associated with poor survival in HIV+ patients (AIDS 2005;19:1091)