Cite this page: Pham, H.P. Pathogen inactivation and transfusion . PathologyOutlines.com website. http://pathologyoutlines.com/topic/transfusionmedpathogeninactivation.html. Accessed January 21st, 2018.
Definition / general
- Additional layer of protection from known and unknown infectious agents (Semin Hematol 2007;44:32), such as leukoreduction (filtration), chemicals and mechanical agents (heat, radiation, fractionation)
- Techniques may damage blood products or have their own side effects
- Examples: methylene blue for fresh frozen plasma (Vox Sang 2007;92:319), photochemical treatment with amotosalen and ultraviolet A for parvovirus B19 (Transfusion 2007;47:1062), S-303 for red cells (Transfusion 2006;46:1778)