Transfusion medicine
Transfusion side effects
Microchimerism

Author: Huy Phu Pham, M.D. (see Authors page)

Revised: 15 November 2017, last major update September 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Microchimerism [title] transfusion

Cite this page: Pham, H.P. Microchimerism. PathologyOutlines.com website. http://pathologyoutlines.com/topic/transfusionmedmicrochimerism.html. Accessed November 23rd, 2017.
Definition / general
  • Chimerism: presence of more than one genetically distinct population of cells in a single organism
  • Microchimerism: stable persistence of an allogeneic cell population, representing < 5% of circulating cells in an individual
  • Due to transplantation, pregnancy or transfusion (Semin Hematol 2007;44:24)
  • Present in 50% of transfused, severely injured patients at hospital discharge (J Trauma 2004;57:702)
  • Injury induces immunosuppressive milieu, leading to persistence of donor WBCs
  • Not affected by leukoreduction (Transfusion 2006;46:1863)
  • No apparent increased risk of transfusion associated graft versus host disease (Blood 2001;98:272)
Clinical features
  • No adverse effects, so not recommended to modify transfusion guidelines or practices
  • Can be prevented by irradiation but microchimerism is NOT an indication for irradiation