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Transfusion medicine

Tranfusion side effects

Hemoglobinopathy (apparent) due to transfusion

Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 8 October 2014, last major update September 2011
Copyright: (c) 2007-2014, PathologyOutlines.com, Inc.


● Due to donor blood with a hemoglobinopathy, most commonly hemoglobin C
● Abnormal hemoglobin ranges from 1-14% of recipient hemoglobin, and recipient often has received multiple transfusions (Arch Pathol Lab Med 2006;130:1830)
● Important to identify to avoid unnecessary testing and treatment; must also notify the donor
● Important to send untransfused sample to test for hemoglobinopathy or red cell enzymatic defects
● Detection of hemoglobinopathies may rarely be suppressed by transfusions (Arch Pathol Lab Med 2005;129:e107)
● See also transfusion associated microchimerism
Case report: Hemoglobin C (Arch Pathol Lab Med 1999;123:642)

End of Transfusion Medicine > Tranfusion side effects > Hemoglobinopathy (apparent) due to transfusion

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