Trachea
Tumors
Papilloma / papillomatosis

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 16 November 2017, last major update October 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Trachea papilloma papillomatosis [title]

Cite this page: Handra-Luca, A. Papilloma / papillomatosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/tracheapapilloma.html. Accessed November 19th, 2017.
Definition / general
Clinical features
  • Juvenile and adult onset
  • Symptoms: cough, hemophtysis
  • May disappear spontaneously
  • May occur in patient with primary biliary cirrhosis, Cowden disease, tuberculosis
  • Cases associated with laryngeal lesions have low incidence of malignant transformation
  • Cases limited to trachea and bronchi usually begin in adults, have higher incidence of malignant transformation
  • Tracheotomy is associated with progression of laryngeal papilloma into trachea (Zhonghua Er Bi Yan Hou Ke Za Zhi 2000;35:384)
Case reports
Treatment
  • HPV vaccine (to prevent); medical therapy, multiple surgery if recurrence
Microscopic (histologic) description
  • Usually benign squamous, intermediate and ciliated cells overlying fibrovascular stroma
  • Invasive tumor may have intracystic papillary structures, atypical invasive epithelium
Differential diagnosis
  • Oat cell carcinoma: looks similar at bronchoscopy