Thyroid gland
Papillary carcinoma
Oncocytic variant

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 23 February 2017, last major update March 2009

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: oncocytic papillary carcinoma thyroid

See also Warthin-like variant
Cite this page: Oncocytic variant. PathologyOutlines.com website. http://pathologyoutlines.com/topic/thyroidoncocytic.html. Accessed May 26th, 2017.
Definition / general
  • Oncocytic (oxyphilic, Hürthle cell like) cytoplasm but nuclear features of papillary carcinoma
  • Up to 10% of papillary thyroid carcinomas
  • Asa suggests that is no logical basis to separate oncocytic lesions from other classifications of thyroid pathology (J Clin Pathol 2004;57:225)
Epidemiology
  • 80% women, ages 34 - 86 years
Clinical features
Gross description
  • Mean 2 cm, mahogany brown
Microscopic (histologic) description
  • Papillary structures at least focally, may be mixed with follicular growth pattern
  • Predominantly oncocytic cytoplasm but papillary nuclear features
  • May be encapsulated or invasive
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Andrey Bychkov, M.D., Ph.D.:

Nuclear pseudoinclusions

Eosinophilic cyto-
plasm, nuclei,
pseudoinclusions,
grooves


Images hosted on other servers:

Complex papillary architecture with thin papillae

Tumor lacks papillae, but has classic nuclear features

Cells have prominent nuclear clearing


More subtle nuclear changes

Cytology description
  • Cellular smears with abundant colloid
  • Round / oval and overlapping nuclei with prominent intranuclear inclusions and grooves and indistinct nucleoli (Acta Cytol 2004;48:137)
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis