Thyroid gland
Other carcinoma
Metastases to thyroid gland

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 3 February 2017, last major update March 2009

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: metastases thyroid gland

Related Topic: Metastases to thyroid gland from kidney
Cite this page: Metastases to thyroid gland. PathologyOutlines.com website. http://pathologyoutlines.com/topic/thyroidmetastatic.html. Accessed April 30th, 2017.
Definition / general
  • 3% of thyroid malignancies are metastases (usually from kidney, lung, breast, melanoma, colon, Cancer 1997;79:574), but most thyroid nodules in patients with nonthyroidal cancer are benign
  • Direct extension common from tumors of pharynx, larynx, trachea, esophagus and neck - usually are squamous cell carcinomas
  • Metastases are found at autopsy in thyroid in 10% of patients dying of cancer, usually melanoma, breast, kidney, lung
  • FNA useful for diagnosis of solitary metastases (Cytojournal 2007;4:5)
Epidemiology
Radiology images

Images hosted on PathOut server:

Xray: metastatic follicular
carcinoma in bone,
contributed by Dr. Mark R. Wick

Case reports
Treatment
Gross images

Images hosted on PathOut server:

Melanoma metastatic from skin primary (AFIP)



Images hosted on other servers:

Invasion by squamous cell carcinoma of larynx

Microscopic (histologic) description
  • Often involves multiple areas of gland
Microscopic (histologic) images

Scroll to see all images.


Images hosted on PathOut server:

Breast carcinoma, AFIP images:

Lobular carcinoma and entrapped thyroid follicles

ER stains breast tumor but not papillary carcinoma

Falsely positive thyroglobulin staining



Lung, AFIP images:

Carcinoid tumor with well defined nesting pattern

Carcinoma metastatic to mediastinal thyroid gland



Other:

Melanoma

Metastatic follicular
carcinoma in bone, TTF1 stain,
contributed by Dr. Mark R. Wick



Uterus:

Case of the Week #342: metastatic leiomyosarcoma (frozen section slides)

Case of the Week #342: metastatic leiomyosarcoma (permanent sections)



Images hosted on other servers:

Breast carcinoma:

Various images



Lung:

Small cell carcinoma

Squamous cell carcinoma



Other:

Melanoma

Parotid adenoid cystic carcinoma

Rectal carcinoma
to poorly differentiated
thyroid carcinoma

Cytology images

Images hosted on other servers:

Esophageal squamous cell carcinoma

Lung squamous cell carcinoma

Melanoma

Melanoma - HMB45

Parotid gland adenoid cystic carcinoma

Positive stains
  • Mucins (usually, but rare in thyroid carcinoma)