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Thyroid gland
Other malignancies
Lymphoma

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 13 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See subtypes below: follicular, Hodgkin

General
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Epidemiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Gross description
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Gross images
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Diffuse large cell lymphoma:
Fish-flesh cut surface (AFIP)
Asymmetric enlargement of gland
Necrotic center surrounded by tan fleshy tissue
Micro description
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Micro images
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Diffuse large B cell lymphoma:
Large pleomorphic cells
Large cell type, reticulin stain, contributed by Dr. Mark R. Wick

AFIP images: diffuse large B cell lymphoma:
Tumor cells grow between non-neoplastic follicles
Note follicle in lower right
Fibrous bands compartmentalize tumor cells
Tumor cells are LCA+, follicular cells are LCA-
Tumor cells entrap and infiltrate thyroid follicles
MALT lymphoma:
Centrocyte-like cells, lymphoepithelial lesions
Lymphocyte "stuffing" of glandular lumina

Other lymphoma:
Follicular lymphoma with residual thyroid follicles (AFIP)
Cytology description
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Cytology images
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Diffuse large B cell lymphoma:
Large and irregular lymphoid cells
Diffuse large B cell lymphoma misdiagnosed as anaplastic carcinoma
High grade lymphoma shows atypical cells
CD45/LCA+, CD20+, keratin negative
Large cell type, contributed by Dr. Mark R. Wick

Other:
Intermediate grade lymphoma
MALT lymphoma
Positive stains
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Molecular / cytogenetics description
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Differential diagnosis
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Additional references
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Follicular lymphoma
General
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Micro description
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Micro images
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Morphology
Negative for bcl2 and IGH-BCL2
Positive for bcl2 and IGH-BCL2


Hodgkin lymphoma
General
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Case reports
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Gross images
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Nodular sclerosing subtype (AFIP)
Micro images
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Nodular sclerosing subtype (AFIP)
Histologic findings
Cytology description
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Cytology images
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Large atypical cells
Additional references
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End of Thyroid gland > Other malignancies > Lymphoma


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