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Thyroid gland
Other carcinoma
Insular carcinoma

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 13 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See also poorly differentiated carcinoma with rhabdoid features

General
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Terminology
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Epidemiology
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Clinical features
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Prognostic factors
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Case reports
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Gross description
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Gross images
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Tumor has replaced most of thyroid gland and has invasive growth pattern, multiple foci of necrosis exist (AFIP)
Massive cervical lymph node metastasis (AFIP)
(A) Well demarcated tumor with prominent vascularity
Contributed by Dr. Mark R. Wick
Micro description
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Micro images
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Insular pattern with clefts
Various images
Small monotonous tumor cells
Insular pattern (b)
Well defined nests and islets of small neoplastic cells
Insular carcinoma images contributed by Dr. Mark R. Wick
Images from AFIP:
Well defined nests (insulae) of tumor cells
Insulae composed of small, monotonous tumor cells
Solid pattern and abortive follicles with colloid
Solid growth pattern with prominent vessels
Peritheliomatous pattern due to necrosis
Tall appearance of epithelium
Transformation from papillary carcinoma to insular carcinoma
Focal insular pattern in follicular carcinoma
Tumor has follicular, trabecular and insular patterns
Various images
Stains:
Focal thyroglobulin+
Cytology description
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Cytology images
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Nesting pattern of cells
Cellular smear has overlapping cells with round, regular nuclei
Large clusters and single cells, inset shows vacuolated cytoplasm
Cellular nests of loosely cohesive cells
Overlapping cells with mild atypia
Small microfollicle of tumor cells
Cells have finely vacuolated cytoplasm and round / oval nuclei
Positive stains
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Negative stains
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Differential diagnosis
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Poorly differentiated carcinoma with rhabdoid features
General
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Case reports
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Micro description
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Micro images
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Nodular and trabecular patterns
Well defined trabeculae
Poorly defined trabeculae composed of cells with vesicular nuclei and prominent nucleoli
Eosinophilic cytoplasmic inclusions
Thyroglobulin negative cells
Positive stains
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Negative stains
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Electron microscopy images
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Well defined cytoplasmic inclusions
Inclusions are composed of intermediate filaments
Differential diagnosis
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End of Thyroid gland > Other carcinoma > Insular carcinoma


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