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Thyroid gland
Hyperplasia / goiter
Graves’ disease

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 10 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Terminology
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Epidemiology
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Laboratory
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Case reports
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Treatment
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Clinical images
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Rodney Dangerfield
Marty Feldman
Gross description
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Gross images
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Markedly enlarged gland
Micro description
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Micro images
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Prominent infoldings of hyperplastic epithelium
Epithelium is tall columnar, colloid shows scalloping
No nuclear changes of papillary thyroid carcinoma
Various images
Numerous plasma cells
Follicles with pale colloid
Irregular follicles with pseudopapillary epithelium and sparse colloid
Colloid has scalloped margins
Lobulated parenchyma with irregular follicles
Follicles with tall epithelium and sparse colloid
Figure 2B - mild atypia
Graves’ versus papillary thyroid carcinoma: H&E and p27
Images from AFIP:
Diffuse hyperplasia with well developed papillae
Follicular cells lining papillae are tall and columnar
Hyperplastic small follicles
Skin:
Pretibial myxedema
Images contributed by Dr. Mark R. Wick:
Virtual slides
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Diffuse hyperplasia and hypertrophy
Diffuse hyperplasia (pathologic)
Hyperplastic follicles are lined by tall columnar cells
Epithelium is tall and columnar; crowding of cells leads to formation of papillae
Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Videos
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"Histopathology Thyroid--Graves Disease"
by John R. Minarcik, M.D.


"Histopathology Thyroid--Graves Disease 2"
by John R. Minarcik, M.D.

Differential diagnosis
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DD of thyrotoxicosis (other than Graves' disease):
Additional references
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End of Thyroid gland > Hyperplasia / goiter > Graves’ disease


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