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General
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Epidemiology
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Clinical features / diagnosis
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Laboratory
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Radiology
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Case reports
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Treatment
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Gross description
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Gross images
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Well circumscribed tumor
Thin capsule
Well encapsulated
Central scar
Cystic and partially necrotic tumor
Contributed by Dr. Mark R. Wick
Images from AFIP:
Encapsulated, homogeneous tan cut surface
Bisected adenoma has fresh hemorrhage
Marked necrosis, hemorrhage and cystic change
Marked cystic degeneration

Micro description
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Micro images
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Images from AFIP:
Thin and uniform fibrous capsule
Marked fibrosis and stromal hyalinization
Marked hyaline thickening of vessel walls
Marked fibrosis, hyalinization and calcium deposition
Marked vascularization resembles a vascular neoplasm
Capsular vessel with smooth muscle cells
Bizarre nuclei
Large, extremely irregular nuclei
With papillary hyperplasia
With papillary hyperplasia and adipose metaplasia
Cartilaginous metaplasia (adenochondroma)
Toxic adenoma is solitary and unencapsulated
Prominent clear cell change
Squamous metaplasia
Mucin production
Other images:
Trabecular type
Bizarre nuclei
Clear cell adenoma
Adjacent atrophic follicular epithelium
Patterns:
Macrofollicular
Microfollicular with sharp circumscription by delicate fibrous capsule
Microfollicular
Microfollicular
Microfollicles have regular nuclei and interfollicular edema
Encapsulated microfollicular adenoma
Microfollicular, trabecular and solid
Insular
Spindle cell type
Patterns from AFIP:
A: solid, B: trabecular, C: microfollicular, D: macrofollicular
Left: macrofollicular, right: solid pattern
Signet ring
Atypical adenomas (AFIP)
Markedly cellular with irregular growth
Well formed follicles merge with solid pattern
Spindle cells mix with round cells
Not invasion:

Fine needle induced changes resemble invasion (AFIP)
Stains:
Signet ring follicular adenoma is thyroglobulin+ (AFIP)
Signet ring pattern, Alcian blue+
H&E, HBME1, CK19
Contributed by Dr. Mark R. Wick:
Cellular follicular adenoma

Virtual slides
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Follicular adenoma of the thyroid

Cytology description
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Cytology images
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Microfollicular
Microfollicular
Macrofollicular
FNA and H&E
Round hyperchromatic nuclei

Positive stains
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Negative stains
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Electron microscopy images
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AFIP Images:
Missing Image

Abundant dilated endoplasmic reticulum

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Microvilli project into well developed lumina

Missing Image

Signet ring follicular adenoma

Molecular / cytogenetics description
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Videos
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Histopathology Thyroid --Follicular adenoma (microfollicular)
by John R. Minarcik, M.D.

Differential diagnosis
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End of Thyroid > Benign neoplasms > Follicular adenoma



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