Thyroid gland
Hyperplasia / goiter
Amyloid goiter

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 19 January 2017, last major update March 2009

Copyright: (c) 2003-2017,, Inc.

PubMed Search: amyloid goiter thyroid
Cite this page: Amyloid goiter. website. Accessed May 26th, 2017.
Definition / general
  • Amyloid deposits in thyroid associated with goiter and not with a neoplasm
  • Very uncommon
  • Diagnosis often made at autopsy (Am J Clin Pathol 1995;104:306)
  • Rapid enlargement of gland (months), diffuse, nontender, may have obstructive symptoms, patients usually euthyroid
  • Often males, median age 54 years, range 23 - 75 years
  • Due to primary or secondary amyloidosis, usually AA type
Case reports
  • Thyroidectomy to relieve pressure symptoms, treatment of underlying systemic amyloidosis (Thyroid 2007;17:77)
Gross description
  • Enlarged, white-tan
Gross images

Images hosted on PathOut server:

Enlarged and bosselated with salmon cut surface (AFIP)

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Lipomatosis and amyloidosis

Microscopic (histologic) description
  • Diffuse amyloid deposition surrounding thyroid follicles, may distort / compress architecture, occasional foreign body giant cell reaction, fatty metaplasia, squamous metaplasia or focal lymphocytic thyroiditis
Microscopic (histologic) images

Images hosted on PathOut server:

Amyloid and inflammatory cells

Apple green birefringence

Case of Week #247

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Birefringent apple green staining under polarized light

Congo red

Calcitonin negative

Various images

Positive stains
  • Congo red shows salmon color and birefringence of apple green staining under polarized light
Negative stains
Differential diagnosis