Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Thyroid gland
Other carcinoma
Anaplastic carcinoma

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 13 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See variants below: paucicellular, rhabdoid

General
=========================================================================
Terminology
=========================================================================
Epidemiology
=========================================================================
Pathophysiology
=========================================================================
Clinical features
=========================================================================
Radiology images
=========================================================================
CT scan - images contributed by Dr. Mark R. Wick
Case reports
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Gross images
=========================================================================
Encapsulated tumor with focal necrosis
Large necrotic tumor
Nodular tumor
Solid and cystic tumor
Contributed by Dr. Mark R. Wick
Images from AFIP:
Scant residual thyroid
Metastases to stomach with ulcerated center
Micro description
=========================================================================
Micro images
=========================================================================
Partially necrotic tumor
Large pleomorphic tumor cells
Pleomorphic and hyperchromatic cells
Contributed by Dr. Mark R. Wick
With osteoclast-like giant cells
Arising from papillary carcinoma
HNPCC syndrome-related (fig b)
Various patterns
Images from AFIP:
Squamoid differentiation with central necrosis
Elongated spindle cells
Storiform pattern resembles MFH
Focally prominent myxoid pattern and extensive inflammation
Hemangiopericytoma-like growth pattern
Diffuse infiltration into perithyroidal fat, resembling lymphoma
Bone formation
Vascular invasion (AFIP):
Tumor invades wall of vein
Tumor thrombus in partially calcified artery
Intravascular tumor thrombus
Giant cells (AFIP):
Numerous giant cells
Bizarre nucleated tumor giant cells
Numerous osteoclast-like giant cells
Contributed by Dr. Stephen J. Schultenover, Vanderbilt University, Tennessee (USA):
Spindled tumor
Spindled tumor
AE1-AE3
CK903
Transformation from well differentiated to undifferentiated carcinoma (AFIP):
Spindled pattern with residual papillary carcinoma
Follicular carcinoma (left) and anaplastic component (right)
Insular component (left), cartilaginous features (right)

Various images
Spread / metastases (AFIP):
Direct invasion of trachea
Metastasis in wall of colon
Metastases to lung
Stains:
Cyclin D1 (fig D)
Rb gene (fig B)
Keratin stains many mesenchymal-like tumor cells (AFIP)
Focal CEA staining (AFIP)
Thyroglobulin stains
Fibrosing variant, keratin stain, contributed by Dr. Mark R. Wick
Cytology description
=========================================================================
Cytology images
=========================================================================
Bizarre tumor giant cells
Atypical cells
Highly pleomorphic cells with prominent nucleoli
Giant cell type has large, bizarre cells
Spindle cell type has dyscohesive spindled cells
Positive stains
=========================================================================
Negative stains
=========================================================================
Electron microscopy description
=========================================================================
Electron microscopy images
=========================================================================

Images from AFIP:
Tumor cells appear extremely primitive
Retention of microvilli
Molecular / cytogenetics description
=========================================================================
Additional references
=========================================================================


Paucicellular variant of anaplastic carcinoma
General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Positive stains
=========================================================================
Negative stains
=========================================================================


Rhabdoid variant of anaplastic carcinoma
General
=========================================================================
Epidemiology
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Various images
Cytology, gross, H&E
Virtual slides
=========================================================================
Rhabdoid variant
Positive stains
=========================================================================
Negative stains
=========================================================================
Electron microscopy description
=========================================================================
Molecular / cytogenetics description
=========================================================================
End of Thyroid gland > Other carcinoma > Anaplastic carcinoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).