Testis and epididymis
Infertility
Klinefelter syndrome

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 4 April 2017, last major update September 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Klinefelter syndrome [title] infertility

Cite this page: Klinefelter syndrome. PathologyOutlines.com website. http://pathologyoutlines.com/topic/testisklinefelter.html. Accessed July 24th, 2017.
Definition / general
  • 47XXY, reduced body and pubic hair, gynecomastia in 40 - 80%, high FSH, variable LH
  • Increased risk of breast cancer and extragonadal germ cell tumor
Gross description
  • Small, firm testes
Microscopic (histologic) description
  • Reduced number of intratubular germ cells, some tubules are Sertoli cell only
  • Also tubular sclerosis, Leydig cell nodules (appear hyperplastic due to tubular atrophy), focal spermatogenesis rarely seen
Microscopic (histologic) images

Images hosted on other servers:

Small hyalinized seminiferous tubules

Atrophy of seminiferous tubules

Hyalinized seminiferous tubules

Electron microscopy description