Stomach
Gastritis
Russell body gastritis

Authors: Natalya Shlyakhova, M.D, Yuxin Lu, M.D. (see Authors page)

Revised: 10 March 2017, last major update March 2017

Copyright: (c) 2017, PathologyOutlines.com, Inc.

PubMed search: Russell body gastritis

Cite this page: Russell body gastritis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stomachrussellbody.html. Accessed November 21st, 2017.
Definition / general
  • Russell body gastritis, first described in 1998, is a reactive gastric mucosal infiltration of plasma cells filled with cytoplasmic Russell bodies (Am J Hematol 2010;85:951)
  • Recently recognized pseudotumoral lesion of the gastric mucosa with unknown etiology; characterized by the accumulation of numerous plasma cells containing Russell bodies (RBs) with the expression of kappa and lambda light chains (J Gastrointestin Liver Dis 2012;21:97)
  • Often associated with H. pylori infection and malignancies such as lymphoplasmacytic lymphoma, plasmacytoma, signet ring cell carcinoma (Pathol Res Pract 2007;203:457, Virchows Arch 2005;446:463)
Essential features
  • Russell bodies, first described by Russell in 1890, are considered to represent aggregates of immunoglobulins resulting from secretory disturbance of plasma cells
  • Plasma cells with Russell bodies can be seen in a variety of mucosal surfaces, including gastrointestinal tract in association with chronic inflammation such as H. pylori gastritis.
ICD-10 coding
  • 2017 ICD-10-CM Diagnosis Code K29.70 - Gastritis, unspecified, without bleeding
Epidemiology
  • Only 39 cases involving the gastrointestinal tract have been reported in English literature, which include Russell body gastritis, duodenitis and esophagitis (Int J Surg Pathol 2015;23:667)
Sites
Pathophysiology
  • Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated rough endoplasmic reticulum cisternae (Int J Surg Pathol 2015;23:667)
  • Considering the other cases reported in the literature, it seems as if H. pylori plays an active role in the etiology of the condition, either by promoting it or by modulating the extension of the disease locally (J Gastrointestin Liver Dis 2012;21:97)
Clinical features
  • Asymptomatic or symptoms related to H. pylori or associated malignancy
Diagnosis
  • Histology showing diffuse infiltration with plasma cell filled with Russell bodies
  • Exclusion of other associated conditions
Radiology description
Prognostic factors
  • Although RBG is by itself a benign condition, its long term effect, such as its possible increased risk for the development of neoplasia, is unknown (J Gastrointestin Liver Dis 2012;21:97)
Case reports
Treatment
  • Treatment of H. pylori usually results in the resolution of Russel bodies in cases associated with H. pylori
Gross description
Gross images

Images hosted on other servers:

Large, irregular and deep
ulcerated mass lesion with central
ulceration at the incisura angularis

Microscopic (histologic) description
  • Plasma cell infiltrates with extensive formation of Russell bodies (Mott cells) within the lamina propria of the antral mucosa
  • Intracytoplasmic inclusions, homogeneous, mainly round to oval, which push the nucleus toward the periphery
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #410:

H&E


Positive for CD138 stain

Positive stains
Negative stains