Fundic gland polyp

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 25 May 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: Fundic gland polyp
Cite this page: Fundic gland polyp. website. Accessed November 19th, 2017.
Definition / general
  • Single or multiple small (2 mm) polypoid projections in gastric fundus / body
  • Considered to be hamartomas or peculiar form of hyperplastic polyp
  • Either sporadic or associated with familial adenomatosis polyposis syndrome, tuberous sclerosis
  • Multiple polyps associated with proton pump inhibitors
  • Fundic gland cysts are associated with increasing periods of treatment with omeprazole for GERD, and with H. pylori eradication (Hum Pathol 2000;31:684)
  • In familial adenomatous polyposis syndrome, occur with increased frequency, 25% are dysplastic vs. 1% of sporadic fundic gland polyps (Am J Surg Pathol 1998;22:293)
  • Sporadic cases associated with loss of immunoreactivity for tuberin, a protein altered in tuberous sclerosis (Mod Pathol 2002;15:862)
  • Patients with 10+ polyps often have beta-catenin mutations (Mod Pathol 2002;15:718)
Case reports
  • 27 year old man with familial adenomatous polyposis (FAP) and multiple gastric polyps (Case of the Week #389)
Gross description
  • Minute mucosal bumps 1 - 5 mm, usually 1 - 20, may be part of diffuse fundic gland polyposis (100+ polyps)
Gross images

Images hosted on other servers:

50 year old woman taking proton pump inhibitors for 10 years

Microscopic (histologic) description
  • Dilated glands / microcysts lined by fundic epithelium
  • Shorted foveola, increased smooth muscle in lamina propria, no proliferation of foveolar epithelium
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #389:





Contributed by Dr. Anne Herdman, PathGroup / Associated Pathologists, Tennessee (USA): fundic gland polyp with dysplasia