Stomach
Other non-neoplastic lesions
Gastric antral vascular ectasia (GAVE)

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 29 November 2016, last major update July 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: gastric antral vascular ectasia
Cite this page: Gastric antral vascular ectasia (GAVE). PathologyOutlines.com website. http://pathologyoutlines.com/topic/stomachantralvascularect.html. Accessed May 29th, 2017.
Definition / general
  • Also called watermelon stomach
  • Rare acquired vascular disease that may cause blood loss and iron deficiency anemia due to chronic antral hemorrhage
  • Associated with connective tissue diseases, particularly systemic sclerosis, but etiology unclear (Arch Pathol Lab Med 2002;126:375)
  • 70% occur in elderly women
  • Endoscopy: parallel red stripes (hyperemic streaks) at antral mucosal folds resemble watermelon stripes (Endoscopy 2004;36:640)
Treatment
  • Iron supplementation in mild cases
  • Argon laser photocoagulation or antrectomy in severe cases
Clinical images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Minimal changes
  • Increase in blood vessel number and diameter with fibrin thrombi, fibromuscular hyperplasia (Am J Surg Pathol 1987;11:750)
  • Reactive foveolar epithelial changes, resembles reactive gastropathy
Microscopic (histologic) images

Images hosted on other servers:

Various images

Differential diagnosis
  • Dieulafoy's lesion / caliber persistent artery of stomach: large diameter artery in gastric submucosa that compresses mucosa, causing erosion, bleeding from artery; 60% mortality
  • Portal hypertension: causes vascular ectasia with different endoscopic appearance, no acute erosions, no fibrin thrombi