Stomach
Other nonneoplastic
Proton pump inhibitors
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 1 September 2020
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: proton pump inhibitors[title]
Cite this page: Weisenberg E. Proton pump inhibitors. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachPPI.html. Accessed April 23rd, 2024.
Definition / general
- Includes omeprazole, lansoprazole, dexlansoprazole, esomeprazole, rabeprazole
- Used to treat gastroesophageal reflux disease (GERD)
- Patients may develop G cell and enterochromaffin cell-like hyperplasia, secondary to drug induced achlorhydria
- Long-term therapy associated with fundic gland polyps (sessile, multiple, < 1.0 cm) in 17% after 3 months, in 35% after 5 months treatment
- Polyps regress when treatment stops (Hum Pathol 2000;31:684)
Microscopic (histologic) description
- Glandular luminal dilatation with swelling and bulging of the superficial cytoplasm of parietal cells (so-called parietal cell protrusion)
- Glands lined by cells with serrated rather than a smooth border
