Cite this page: GE junctional adenocarcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stomachGEJ.html. Accessed January 21st, 2018.
Definition / general
- Based on AJCC Cancer Staging Manual (7th ed, 2010), adenocarcinoma arising in gastroesophageal junction and proximal 5 cm of stomach is staged as esophageal cancer
- Heterogeneous group of tumors, but most arise from distal esophagus associated with Barrett's esophagus; cardia adenocarcinomas and subcardial gastric carcinomas which secondarily invade GE junction also occur
- Distal esophageal tumors: usually men, associated with Barrett's esophagus (intestinal metaplasia) and reflux, less likely to have diffuse growth pattern, lower incidence of lymphatic spread, CK7+
- Cardia tumors: usually men, usually not associated with Barrett's esophagus, higher frequency of diffuse pattern, although most are still intestinal