Stains
Survivin

Author Nat Pernick, M.D. (see Authors page)

Revised: 10 December, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Survivin[title]

Cite this page: Survivin. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainssurvivin.html. Accessed December 11th, 2017.
Definition / general
  • Inhibitor of apoptosis protein; may also enhance proliferative activity of tumor cells
  • Overexpression enhances cell survival
Interpretation
  • Cytoplasmic staining
Positive staining - normal
  • Fetal tissues
Positive staining - disease
  • Hepatocellular carcinoma, endometrial carcinoma
Negative staining
  • Most normal, terminally differentiated tissue