Cite this page: Sialyl-Tn antigen. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainssialyltn.html. Accessed August 21st, 2017.
Definition / general
- Also called CD175s
- Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
- Presence associated with aggressive tumors
- High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
- Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining - disease