Stains
PAX8

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 February 2017, last major update November 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: PAX8

Cite this page: PAX8. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainspax8.html. Accessed October 21st, 2017.
Definition / general
  • Also called Paired box 8
  • Discovered in 1990 (Development 1990;110:643)
  • Paired domains are composed of two helix-turn-helix subdomains
    • The N-terminal subdomain and the C-terminal subdomain, both of which can bind DNA independently (Cell 1995;80:639)
  • Structurally similar to PAX2 and PAX5
Pathophysiology
Interpretation
  • Nuclear staining
  • Actually negative in B cell lymphomas, but reported positive due to cross reactivity between the N-terminal regions of PAX8 and PAX5, due to the high sequence homology of these two regions (Mod Pathol 2012;25:231)
Uses by pathologists
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Andrey Bychkov, M.D., Ph.D.:

Expression by thyroid follicular cells

Papillary thyroid carcinoma, PAX8



Images hosted on other servers:

Missing Image

Kidney

Missing Image

Normal adult kidney

Missing Image Missing Image

Renal epithelial tumors

Missing Image

Thyroid carcinomas

Missing Image

Urothelial carcinoma

Positive staining - normal
  • Epithelium of endocervix, endometrium, fallopian tubes, kidney (glomerular parietal epithelial cells, renal collecting ductal cells, atrophic renal tubular epithelial cells, Mod Pathol 2011;24:751), thyroid
  • Ovarian inclusion cysts, pancreatic islet cells
  • Epithelium of male genital tract from rete testis to ejaculatory duct, but not prostate
Positive staining - disease
Negative staining