Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update January 2013

Copyright: (c) 2002-2015,, Inc.

PubMed Search: OPA1 [title]

Cite this page: OPA1. website. Accessed April 23rd, 2017.
Definition / General
  • Optic atrophy 1 protein (OPA1): 112 kd guanosine triphosphatase involved in mitochondrial inner membrane fusion and anticancer drug-mediated cytotoxicity
  • Associated with autosomal dominant optic atrophy, characterized by selective degeneration of retinal ganglion cells (Jpn J Ophthalmol 2012;56:91, J Neurol Sci 2012;315:146)
Uses by Pathologists
  • No significant current use
Positive Staining - Disease
Electron Microscopy Images
Missing Image

Loss of OPA