Stains
NeuN

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 November 2015, last major update September 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: NeuN [title]

Cite this page: NeuN. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainsneun.html. Accessed May 27th, 2017.
Definition / general
  • Nuclear protein (neuronal nuclear antigen) widely expressed in mature postmitotic neurons and used as a biomarker for neurons (Wikipedia)
  • Is the FOX3 gene product (J Neurosci Methods 2005;148:26)
  • Considered a marker of neuronal differentiation in brain tumors; present in all major subtypes except pilocytic astrocytoma
Uses by pathologists
Microscopic (histologic) images

Images hosted on Other servers:

Missing Image

Section of cortex

Missing Image

Middle temporal gyral neocortex

Missing Image

Neuronal density changes

Missing Image

Changes in neuronal size

Missing Image

Neuropathological features

Positive staining - normal
  • Mature postmitotic neurons
Positive staining - disease
Negative staining