Stains
Laminin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Laminin[title]

Cite this page: Laminin. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainslaminin.html. Accessed April 28th, 2017.
Definition / general
  • Major component on basement membrane, with type IV collagen
  • Trimeric glycoproteins (at least 11 types) with integrin binding site
  • Defects in laminin proteins cause skin blistering and myocardial diseases
  • Antibodies to laminin inhibit lung branching morphogenesis
  • Production of alpha-1 laminin by epithelial cells and mesenchymal cells depends on extent of mesenchymal and epithelial contact with each other; modulates mesenchymal cell shape
Uses by pathologists
Microscopic (histologic) images

Laminin5 expression in normal breast, DCIS and invasive ductal breast carcinoma