Cite this page: Hales colloidal iron. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainshales.html. Accessed November 21st, 2017.
Definition / general
- Kidney tumors: stain must have pH between 1.5 and 2.0
- Clear cell and papillary renal carcinoma have focal, coarse, droplike staining
- Note: hemosiderin in any tumors will also stain positive
Uses by pathologists
- Helpful in distinguishing chromophobe renal cell carcinoma (intensely positive in large percentage of cells with reticular staining) from oncocytoma (usually negative; if positive - fewer cells with less intensity and dustlike staining)