Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 June 2016, last major update January 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: GATA3
Cite this page: GATA3. website. Accessed April 23rd, 2017.
Definition / General
  • One of 6 members of GATA family of transcription factors
  • Luminal marker for breast epithelium; also master regulator of helper T cells type 2
Clinical Features
  • GATA3 mutations cause HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome (Endocr J 2011;58:117)
Uses by Pathologists
  • Low nuclear GATA3 immunoexpression may be poor prognostic factor for invasive breast cancer (Hum Pathol 2010;41:1794)
Micro Images

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Breast tissue (various)

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Breast cancer (invasive ductal), figure C

Positive Staining - Normal
  • A nuclear stain
  • Breast epithelium, T cells (mature)
Positive Staining - Disease
Negative Staining
  • Breast myoepithelial cells