Stains
Bombesin


Author: Rebecca Obeng, M.D. (see Authors page)

Revised: 6 July 2017, last major update July 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Stains bombesin[title]
Cite this page: Bombesin. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainsbombesin.html. Accessed November 24th, 2017.
Definition / general
  • Class of secreted neuropeptides (called bombesin related peptides) comprised of gastrin releasing peptide / neuromedin C and neuromedin B
  • Stimulates the release of gastrin from G cells, regulates appetite and neuropathic pain, functions in the immune system
  • Neuromedin B inhibits thyroid stimulating hormone and is involved in smooth muscle contraction
  • Exerts function via G protein coupled receptors (GRPR (BB2) and NMBR (BB1))
Essential features
  • Neuropeptides that stimulate the release of gastrin and regulate fear (Behav Brain Res 2007;179:133)
  • Neuromedin C / gastrin releasing peptide serves as a chemoattractant, acts on phagocytic cells to stimulate phagocytosis (Neuropeptides 1991;20:217), suppresses appetite, regulates stress (Expert Opin Ther Targets 2016;20:1055)
  • Neuromedin B also plays a role in cytokine release, decreases gastric motility (Fed Proc 1979;38:2315) and excites nociceptors (pain receptors, Pain 2003;104:609)
  • Secreted by many tumor cells and promotes tumor growth
  • Receptors for neuromedin B and gastrin releasing peptide / neuromedin C are overexpressed by, and promote tumor growth in tumors of breast, CNS, colon, head and neck, lung, pancreas and prostate
Terminology
  • Neuromedin B, neuromedin C, gastrin releasing peptide, GRP 10
Sites
  • Neuromedin B: CNS, gastrointestinal tract, pancreas, adrenal medulla, pituitary gland, adipose tissue, urinary tract, uterus (PLoS One 2016;11:e0151871)
  • Neuromedin C: CNS (hippocampus, thalamus, spinal cord, olfactory bulb) and gastrointestinal tract (stomach, duodenum) (PLoS One 2016;11:e0151871)
Pathophysiology
  • Produced by many tumor cells, promotes tumor growth by mediating activation of epidermal growth factor receptor and HER2 (Expert Opin Ther Targets 2016;20:1055)
  • Gastrin releasing peptide / neuromedin C have been implicated in duodenal ulcers and lung cancer
  • Neuromedin B is associated with obesity (Front Neurosci 2013;7:193, J Physiol 2010;588:1393)
  • Receptors for neuromedin B and gastrin releasing peptide / neuromedin C are overexpressed in many human tumors including CNS, colon, head and neck, pancreas, lung, breast and prostate (PLoS One 2016;11:e0151871)
Radiology description
Treatment
Board review question #1
    Bombesin-like peptides are a class of neuropeptides whose functions include which of the following?

  1. Inhibition of gastrin secretion
  2. Inhibition of thyroid stimulating hormone
  3. Stimulation of appetite
  4. Suppression of ADH
Board review question #1
B. Neuromedin B is highly expressed in pituitary. It functions to regulate the levels of thyroid hormones by inhibiting the release of thyroid stimulating hormone.