Stains
ATRX

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update February 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: ATRX[title]
Cite this page: ATRX. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainsatrx.html. Accessed June 23rd, 2017.
Definition / general
  • Alpha-Thalassemia/mental Retardation syndrome X-linked
  • Chromatin remodelling protein important in DNA replication, telomere stability, gene transcription, chromosome congression and cohesion during cell division (Epigenetics 2013;8:3)
  • Member of SWI/SNF protein family of DNA dependent ATPases
  • Is recruited to site of DNA damage; required for efficient checkpoint activation and faithful replication restart (J Biol Chem 2013;288:6342)
  • Death domain-associated protein (Daxx) cooperates with ATRX
Clinical features
Uses by pathologists
  • See clinical features above
Microscopic (histologic) images

Images hosted on other servers:

Neuroblastoma

Pancreas: ALT+ tumors

Pancreas: MEN1 microadenoma and
pancreatic neuroendocrine tumor