Stains
AP2 beta / AP2B1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 November 2015, last major update December 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: AP2 beta
Cite this page: AP2 beta. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainsap2beta.html. Accessed November 22nd, 2017.
Definition / general
  • Member of AP2 transcription factor family, which consists of five different yet closely related 50-kDa isoforms
  • Also called adapter protein 2 beta, TFAP2b (transcription factor AP 2 beta), Activating enhancer-binding protein-2β
Pathophysiology
  • Regulates expression of many downstream genes, orchestrating a variety of cell processes, particularly cell induction, differentiation, survival, and proliferation and apoptosis within various developmental contexts (Mol Cancer 2014;13:89, Ann Thorac Surg 2011;92:1044)
  • Assembly protein associated with clathrin-coated vesicles, involved in endocytosis and Golgi processing (Genomics 1995;30:94)
  • Involved in monoaminergic transmission, likely due to a regulatory effect on monoamine oxidase type A and serotonin transporter (Brain Res 2009;1305 Suppl:S20)
Clinical features
Uses by pathologists
Microscopic (histologic) images

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Non-small cell lung cancer

Lung cancer cells and tumor tissues