Table of ContentsDefinition / General
Cite this page: AML1. PathologyOutlines.com website. http://pathologyoutlines.com/topic/stainsaml1.html. Accessed March 25th, 2017.
Definition / General
- Gene at 21q22 is DNA binding component of AML1/CBF beta transcription factor complex, most frequent target of translocations in AML via t(8;21) [AML1-ETO]; t(12;21); t(3;21) [AML1-EVI1]
- Fusion products (below) suppress normal AML1 mediated transactivating activity
- Normal AML1 required to establish fetal liver-derived definitive hematopoiesis (stem cells to definitive hematopoietic elements)