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Stains

Gross cystic disease fluid protein 15 (GCDFP-15)

 

Authors: Kara Hamilton, M.S. and Nat Pernick, M.D., PathologyOutlines.com, Inc.

Revised: 2 July 2009, last major update July 2009

 

Terminology

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● Also called BRST2, prolactin-induced protein (PIP)

 

Physiology

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● Glycoprotein originally isolated in human breast gross cystic fluid

 

Uses

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● Differentiate breast carcinoma metastatic to ovary (positive) from primary ovarian carcinoma (negative)

● Marker of apocrine differentiation, including apocrine carcinoma of breast, although B72.3 may be more sensitive and specific (APMIS 2006;114:712)

● Less sensitive but more specific than mammaglobin in breast carcinoma in tissue (Am Jour Clin Path 2007;127:103) and similar findings in fluids (Diagn Cytopathol 2009;37:475), but mammaglobin more specific in metastatic breast carcinoma to lung and pleura (Arch Pathol Lab Med 2008;132:239)

● Differentiating primary vulvar Paget’s disease (positive) from vulvar Paget’s disease secondary to carcinoma (negative, Arch Path Lab Med 1998;122:1077)

 

Positive stains

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● Normal adults - all apocrine, lacrimal, ceruminous and Moll's glands; all cutaneous eccrine glands; numerous serous cells of submandibular, sublingual and minor salivary glands; also serous cells of nasal and bronchial glands (Virchows Arch 1998;432:255)

● Lobular breast carcinoma (90%)

● Primary breast carcinoma (72%)

● Metastatic breast carcinoma (80%)

● Salivary gland carcinoma (Mod Pathol 1998;11:1033)

● Lung adenocarcinoma with apocrine features (Am J Surg Pathol 2008;32:426)

● Papillary hidradenoma (Archives 1991;115:1249)

● Vulva - primary Paget’s disease (see Vulva chapter of PathologyOutlines.com) and primary breast carcinoma

● Prostate carcinoma (Hum Pathol 1989;20:281)

 

Negative stains

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● Vulvar Paget’s secondary to carcinoma (Hum Path 2002;33:545)

● Serous papillary adenocarcinoma of female genital tract (Hum Path 2008;39:666)

● Ovarian carcinoma (AJSP 2005;29:1482)

 

Micro images

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Breast (benign)

 

 

                                    

Invasive apocrine carcinoma                         

of the breast                                                       

 

 

Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author          Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author                       

Neuroendocrine carcinoma of breast          Poorly differentiated breast

                                                                                carcinoma (fig 2C)

 

 

Metastatic lobular carcinoma

in an endometrial polyp

 

 

                i1543-2165-129-3-338-f03                                 

Breast carcinoma metastatic         Breast carcinoma                             

to lung                                                   metastatic to stomach (fig 3c)      

 

Additional references

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● Sources for GCDFP-15 (advertisements): Covance

 

End of Stains chapter > Gross cystic disease fluid protein 15 (GCDFP-15)

 

 

 

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