Other non-neoplastic disorders
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Also called dysplenism
- Enlarged spleen leads to removal of cellular blood components (some or all), causing thrombocytopenia, neutropenia, hemolytic anemia or pancytopenia
- Due to disorders (congestive splenomegaly, Gaucher's disease, hamartoma, hemangioma, Langerhans' cell histiocytosis, leukemia / lymphoma, other conditions diffusely involving red pulp) causing widening of splenic cords with increase in macrophages or connective tissue, causing premature destruction of normal blood components
- Reactive follicular hyperplasia of white pulp may be present in hypersplenism associated with cytopenias
- Infectious causes include brucellosis, CMV, echinococcus, histoplasmosis, infectious mononucleosis, leishmaniasis, malaria, schistosomiasis, syphilis, toxoplasmosis, trypanosomiasis, tuberculosis, typhoid
- May be due to abnormal cellular blood components (hereditary spherocytosis)
End of Spleen > Other non-neoplastic disorders > Hypersplenism
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