Soft tissue
Fibroblastic / myofibroblastic tumors
Proliferative peribursitis

Author: Cliff Sullivan, M.D. (see Authors page)
Editor: Jerad M. Gardner, M.D.

Revised: 12 September 2016, last major update June 2013

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Peribursitis

Cite this page: Proliferative peribursitis. website. Accessed April 26th, 2017.
Definition / General
  • Reactive, angiomyxoid tumor-like mass near joints and ligaments
  • Not a WHO diagnosis
  • Poorly documented in literature
  • Can occur at any age
Clinical Features
  • Generally a complication of prior joint disease (e.g. degenerative joint disease, ruptured ganglion cyst), dislocation, or trauma
Micro Description
  • Low power: separate vascular and nonvascular regions; vascular region has cluster of thick vessels, often in nodular pattern, with pericyte cuff in myxoid substance
  • High power: evenly disbursed spindle cells with bipolar and stellate cells and scattered lymphocytes and histiocytes; histiocytes may contain vacuoles and resemble lipoblasts; may have cysts, some resembling ganglion cysts, with or without a synovial lining; occasionally have dense scar
Positive Stains
Differential Diagnosis
  • Myxoid liposarcoma: uniform round cells, delicate branching "chicken wire" vasculature, scattered uni- or bi-vacuolated monotonous lipoblasts
  • Myxoma: hypocellular, stellate cells only; no prominent vasculature