Small bowel (small intestine)
Patterns of abnormal small bowel architecture
Variable villus abnormality and crypt hypoplasia
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 3 November 2014, last major update August 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
● Villi focally flat or mild/moderate villus shortening
● Also increased intraepithelial lymphocytosis, decreased crypt mitotic figures
● Marasmus: severe protein-calorie malnutrition
● Kwashiorkor: protein malnutrition but adequate caloric intake
● Megaloblastic anemia: vitamin B12 or folate deficiency, no increased inflammatory cells
● Chemoradiation effect: apoptosis, atypical cells
● Microvillus inclusion disease
End of Small bowel (small intestine) > Patterns of abnormal small bowel architecture > Variable villus abnormality and crypt hypoplasia
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