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Small bowel (small intestine)

Inflammatory disorders

Lymphocytic enterocolitis

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Refractory spruelike condition associated with colonic mucosal abnormalities (Can J Gastroenterol 2008;22:771)

Micro images

Lymphocytic ileitis,: ileal biopsy from 28 year old man with chronic diarrhea shows marked increase in intraepithelial lymphocytes (Courtesy of Dr. Hanni Gulwani)

Lymphocytic colitis related


● High intraepithelial lymphocyte count in terminal ileum biopsies (Mod Pathol 2003;16:115, Am J Surg Pathol 2002;26:1484)
● Normal range of ileal lymphocytes is 0-9 lymphocytes / 100 enterocytes, decreases with age (Am J Clin Pathol 2007;127:816)
● Lymphocytes are mostly suppressor T cells
Symptoms: chronic nonbloody diarrhea, relatively normal endoscopy

Micro images

Terminal ileum with villous atrophy and increase in intraepithelial lymphocytes

End of Small bowel (small intestine) > Inflammatory disorders > Lymphocytic enterocolitis

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