Small intestine & ampulla

Benign tumors / tumor-like conditions

Inflammatory fibroid polyp



Last author update: 1 August 2012
Last staff update: 22 July 2021

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PubMed Search: Inflammatory fibroid polyp small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Inflammatory fibroid polyp. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallbowelinflammatoryfibroidpolyp.html. Accessed March 28th, 2024.
Definition / general
Case reports
Treatment
  • Excision (does not recur)
Gross description
  • Polypoid (without stalk), submucosal mass, dumbbell shape in small intestine due to intussuception, mucosal ulceration and splitting and atrophy of muscularis propria
Gross images

Contributed by Claudia Mendez, M.D.

Inflammatory fibroid polyp

Microscopic (histologic) description
  • Submucosal mixture of prominent capillaries, spindle cells (occasionally concentrically arranged around vessels / onion skinning) and inflammatory cells (particularly eosinophils, plasma cells and mast cells) in granulation tissue-like stroma (Arch Pathol Lab Med 2010;134:378)
  • May be transmural
  • May have lymphoid follicles
  • Rare multinucleated giant cells, no atypia, no / rare mitotic figures
  • Histologic patterns: classical, edematous, fibrovascular, nodular, sclerotic
Microscopic (histologic) images

Contributed by Claudia Mendez, M.D.

4x

10x

40x

Positive stains
Negative stains
  • CD117 (although mast cells are positive)
Differential diagnosis
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