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Small bowel (small intestine)

Benign tumors and tumor-like conditions


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 19 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Neural tumor, usually arises from nerves within bowel wall, may be mucosal
● Multiple tumors are associated with neurofibromatosis type 1, MEN 2b/3; sporadic tumors are usually solitary

Case reports

● 32 year old man with neurofibromatosis type 1 (Ann Diagn Pathol 2009;13:50)
● 42 year old man with benign solitary small intestinal ganglioneuroma presenting with perforation peritonitis (Indian J Gastroenterol 2001;20:31)
● Primary mesentery ganglioneuroma (J Pediatr Surg 2007;42:573)

Gross description

● Polypoid

Micro description

● Proliferation of ganglion cells and Schwann cells in mucosa and deeper layers
● May see accentuation of submucosal and myenteric plexus in MEN 2b/3

Micro images

Ganglioneuroma and ganglioneuromatosis: A-solitary ganglioneuroma presents as a single polyp, but C-diffuse ganglioneuromatosis forms a flat, ill-defined mass lesion; both solitary (B) and diffuse (D) ganglioneuromatosis contain ganglion and neoplastic Schwann cells

Positive stains

● S100, NSE

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Ganglioneuroma

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